Postdoctoral Scientist Neurobiology Dr Michel Goedert LMB 2842 Full Time NEW

Cambridge, Cambridgeshire
UK Research and Innovation
£42,694 per annum

Overall purpose:

To work in the group of Dr Michel Goedert from the Neurobiology Division of the MRC Laboratory of Molecular Biology (LMB), as part of a programme aimed at understanding Molecular Mechanisms of Neurodegeneration. Specifically, to undertake research to develop methods for forming alpha-synuclein filaments with the same structures as those from human brains, This work will be done in close collaboration with the group of Dr Sjors Scheres from the Structural Studies Division of the LMB.

The assembly of alpha-synuclein into abnormal amyloid filaments is central to the development of several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy. Since 2020, we have used electron cryo-microscopy (cryo-EM) to show that specific alpha-synuclein determine the structures of alpha-synuclein filaments from human brains. We have shown that specific filament folds define these diseases. Non-proteinaceous densities of unknown composition are also present. To understand mechanisms of disease, one must be able to form filaments that have the same structures as those from human brains in vitro, in cells and in animals. This may require the addition of cofactors of known identity. One successful candidate will use immunoprecipitation and mass spectrometry to identify the chemical identity of cofactors (in collaboration with Professor P. Barran, University of Manchester), The second candidate will develop methods for making alpha-synuclein folds like those from human brains and use cryo-EM to analyse these folds.

Main duties:
• To undertake research aimed at understanding mechanisms of neurodegeneration.
• To identify, develop and apply a broad range of techniques to pursue the research objectives.
• To present scientific work at seminars within the laboratory and at external meetings.
• To contribute to laboratory-wide discussions on developments within the field.
• To draft scientific papers and contribute to the overall preparation of research for publication.
• To contribute to the LMB’s mission in the public engagement of science and the translation of research findings into improvements in health care.
• To assist in the training of PhD students and other members of the LMB.

Key responsibilities:

Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan.

To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your supervisor.

To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.

To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.

To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.

To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.

To enhance your research and generic skills through a tailored development programme.

Working relationships:

You will report to Dr Michel Goedert and you will interact and collaborate with other Postdoctoral Scientists, Research Support staff and Students, not only in your group, but also across the LMB and with external groups as necessary.

Additional information:

These positions are three-year training and development positions for Postdoctoral Scientists who have recently completed their doctoral studies, are moving into a new research discipline or have limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including:
• MRC training courses.
• External training and personal development courses.
• One-to-one training with your Supervisor and other Scientists.

You will commit to undertaking the following:
• Developing and following a personal development plan.
• Attending training courses.
• Identifying additional training which will support you to develop your career.
Person specification
Academic qualifications:

These should include a PhD in a relevant subject or due to complete a PhD within 6 months.

Technical skills and expertise:

The successful candidates will have experience in the generation of experimental models of amyloid formation and/or cryo-EM/cryo-ET.

Experience in standard molecular biology techniques of cloning and cell culture or protein purification are essential. Experience in mass spectrometry can be an advantage.

Track record of research:

This will include contributions to published papers.

Other relevant evidence of:
• Commitment.
• Originality.
• Ability to communicate.
• Independent working.
• Working with others.

Additional information:

Applicants are required to submit a full CV and cover letter.
Corporate/local responsibilities & requirements
You must carry out your responsibilities with due regard to the UKRI:
• Code of Conduct
• Equality, Diversity and Inclusion policy
• Health and Safety policy
• Data Protection policy

Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between you and your manager.

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI.

The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required in the course of employment.

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As users of the disability confident scheme, any candidate who opts into the scheme and best meets the essential criteria, will be shortlisted for interview. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

How to apply

Online applications only preferred for this role. Please submit a CV and covering letter which clearly outlines how you fulfil the criteria specified along with your motivation for UKRI and the role. Ensure that the job reference number is included in the filename description of each document uploaded. Note that failure to address the above criteria or submit an application without a covering letter may result in the application not being considered.

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Artificial intelligence can be a useful tool to support your application, however, all examples and statements provided must be truthful, factually accurate and taken directly from your own experience. Where plagiarism has been identified (presenting the ideas and experiences of others, or generated by artificial intelligence, as your own) applications may be rejected and internal candidates may be subject to disciplinary action.

As part of the pre-employment checks there is a requirement to undergo Baseline Personnel Security Screening. BPSS is a pre-condition of employment and failure to achieve it may mean that the employment offer is rescinded. UKRI reserves the right to run, or re-run . click apply for full job details